Meloxicam in Rabbits


Anesthetic and analgesic pharmacokinetic studies are continually helping us to revise our dosages and protocols for exotic species. A recent example is Meloxicam use in rabbits; while earlier formularies suggest a dosage of 0.2 mg/kg PO, a 2013 pharmacokinetic study suggested clinically useful dosages are likely much higher. See the following article for more information: Am J Vet Res. 2013 Apr;74(4):636-41                                                                 Pharmacokinetics of meloxicam in rabbits after oral administration of single and multiple doses.                                                                                                                                             Fredholm DV1, Carpenter JWKuKanich BKohles M.

Our current dosage recommendation for short-term use of Meloxicam in well-hydrated, normovolemic rabbits without evidence of renal dysfunction is 0.8-1.0 mg/kg PO. The authors of the study conclude:

"Plasma concentrations of meloxicam for rabbits in the present study were proportionally higher than those previously reported for rabbits receiving 0.2 mg of meloxicam/kg and were similar to those determined for animals of other species that received clinically effective doses. A dose of 1 mg/kg may be necessary to achieve clinically effective circulating concentrations of meloxicam in rabbits, although further studies are needed."